Endocrine Abstracts

Purpose: Thyroid autoimmune diseases occur more frequently in women than men. A previous study reveals that exogenous testosterone may have a protective effect on thyroid autoimmunity in men with Hashimoto’s thyroiditis. But no study has determined whether sex hormones produce any effect on thyroid antibody titreş in women. The primary study aim was to assess whether exogenous testosterone affects thyroid autoimmunity in trans-men with increasing testosterone levels....

Introduction: Erectile dysfunction (ED) is quite common. It poses a problem of diagnosis and management given the multiplicity of contributing factors and etiologies that can sometimes be unrecognized.Observations: We report 3 observations of patients followed for insulin-requiring diabetes. The average age was 51. They had ED for 3.5 years on overage. The clinical examination of our patients showed obesity or weight excess. The impact assessment of diab...

Objective: Androgen may be detrimental for vascular health in women. Sensitivity to androgen is influenced by the CAG repeat length of the androgen receptor (AR) gene. We investigated possible associations between the CAG repeat polymorphism with the severity of CAD in women undergoing coronary angiography.Methods: We examined 131 postmenopausal women (45–88 years). CAD severity was assessed by the number of coronary vessels with >50% stenosis. ...

The vulnerability of early central nervous system (CNS) development to thyroid hormone (TH) deprivation has been highlighted by studies showing an association between maternal hypothyroxinemia during the first trimester and long-term neurodevelopmental delay in the offspring. The molecular mechanisms underlying this observation are, however, poorly understood. It is known that the actions of triiodothyronine (T3), the active TH metabolite, are primarily mediated by TRs, which ...

Background data: Laparoscopic adrenalectomy has became in the last decade “gold standard” for treating of adrenal tumors with diameters smaller than six cm. In addition, one should note than larger tumors or potentially malignant tumors can now also be removed laparoscopically, with virtually no complication.Objective: The authors evaluate the effectiveness of laparoscopic adrenalectomy for a large adrenal tumors.Methods:...

Context and objective: Coping strategies may affect quality of life (QoL), which is decreased in patients after treatment for Cushing’s disease, acromegaly, or non-functioning macroadenomas (NFMA). We aimed to explore coping strategies in these patients, since this has never been done before.Design: A cross sectional study.Subjects: We included patients treated for Cushing’s disease (n=42), for acromegaly (n...

Context and objective: Illness perceptions pertain the pattern of beliefs patients develop about their illness. These views are determinants of behavior directed at the illness. Illness perceptions are determinants of quality of life (QoL). QoL remains impaired in patients after treatment of endogenous hypercortisolism, however, illness perceptions were never studied in these patients. The objective of the current study was to explore illness perceptions and its relation with ...

Angiogenesis is the rate-limiting step in tumour progression and metastatic spread. Both promoters and inhibitors of angiogenesis have been implicated in thyroid tumourigenesis. We have reported PTTG overexpression in thyroid and other cancers, and PTTG upregulation of the angiogenic factors FGF-2 and VEGF in vitro. To investigate whether PTTG also transactivates other downstream angiogenic effectors, we employed angiogenesis-specific cDNA arrays. Primary thyroid cells and PTT...

Current guidelines recommend measurement of rhTSH-stimulated Tg, with neck ultrasound 6–12 months after the initial therapy for DTC (Total thyroidectomy plus 100 mCiI131 ablation of the thyroid bed). Uncertainty persists regarding whether the subsequent follow up should be based on measurement of basal serum Tg or whether rhTSH-stimulated Tg should be performed and at what frequency. The aim of our study was to evaluate the utility of repeated rhTSH-stimulated Tg.<p c...

Glucocorticoid treatment in congenital adrenal hyperplasia (CAH) is a continuous challenge, with even the experienced clinician struggling to strike the right balance between glucocorticoid over- and undertreatment. There is no consensus on monitoring of glucocorticoid therapy in adults with CAH. Some recommend a serum 17-hydroxyprogesterone (17OHP) target range of 12–36 nmol/l prior to glucocorticoid morning dose. Here we investigated the value of serum and urinary stero...